waiting the masterclass about fermented food! the literature around urolothin A is great and this study in humans quite interesting!
and even more interesting the possibility to induce or imprint microbiome to do more for us!
I was not aware about iberian pigs!!!!!!!! great news! here in italy there is a cuty fermendted dairy called "capretta blu" from goat milk!!! and your great combo of bacon Roquefort walnuts would sound amazing! sprinkled with some raspberries or pomegranates :))))))
Ya, the Iberian pork fun fact came from the podcast I linked. Still waiting to hear back from the first author... I have more question, including about the pig data.
I wonder about optimizing the ever-popular microbiome. I ignore mine because it adapts/optimizes in about 24 hours. I let it take care of itself. As an aside, I once met the woman who first "discovered" (maybe popularized) the microbiome - or so she said - I asked for her autograph.
Yes, met a young woman some years ago - sold her something on craigslist - she and her friend stopped by. We got to talking and her friend mentioned that she
"had discovered" the microbiome. This was in the original heyday of its initial popularity, around 2008. (I know it was discovered long ago, like a hundred years ago) I assumed she was a researcher and likely did her dissertation on it. So I jokingly asked for her autograph, which she declined. Back then the microbiome was famous, the key to life. Like DNA. I suppose they were just excited postdocs in a new field. You know how they are.
As always, the supplement industry didn't waste time flooding the online shops with offerings of Urolithin A, and as always, the problem numero uno for us, consumers, is to try to find which brand sell the real stuff.
My point is about the lack of regulations regarding supplements; we have little guarantees, the product advertised is really what it is claimed.
Case in point: relative of mine used to work at BU School of Medicine as an analytical chemist. One of his colleagues is a very well known specialist of analysis of PUFAs, which a difficult endeavor.
EVERY contract he got to analyze the composition of PUFAs for manufacturers came with ironclad NDAs.
Why? Since > 90% of all the products he analyzed had substantially subpar quantity of active ingredients than the manufacturer claimed on the package insert, the request for signing NDAs prior to do the work was…unsurprising.
Crazy significance. Still, differential dose-responses on different muscle groups and also on strength vs. endurance? Them numbers are all over the chart.
That a confounder effect? Maybe time is a hidden confounder. Myostatin, IL-15, or recovery rate effects? Body-type, diet, or outcome-arm non randomization? The often ignored outer-space-alien Ai that's running this reality effect?
Might be good to see results after eight months.
I personally believe that any cohort not wearing Velostat hats is suspect.
I bought some Velostat to line my hats; an experiment to discern a difference - and that shipment of Velostat impossibly disappeared from my desk! Not misplaced, either. I bought more but have not gotten to it yet in over a year; I seem to be blocked from completing my task.
Maybe by these really weird apparent bio-entities:
Yes, modifier is good terminology, but there seems to be more directional modification going on than strength modification, which I'd think should be more common as dose response is more often more is more rather than the reversal, more is less.
With lots of subgroups a modifier could also be a confounder.
This irritated me when first watching your channel. I feel it got more refined and I grew to like it, you're practically inquisitiveness personified. :^)
waiting the masterclass about fermented food! the literature around urolothin A is great and this study in humans quite interesting!
and even more interesting the possibility to induce or imprint microbiome to do more for us!
I was not aware about iberian pigs!!!!!!!! great news! here in italy there is a cuty fermendted dairy called "capretta blu" from goat milk!!! and your great combo of bacon Roquefort walnuts would sound amazing! sprinkled with some raspberries or pomegranates :))))))
Ya, the Iberian pork fun fact came from the podcast I linked. Still waiting to hear back from the first author... I have more question, including about the pig data.
I wonder about optimizing the ever-popular microbiome. I ignore mine because it adapts/optimizes in about 24 hours. I let it take care of itself. As an aside, I once met the woman who first "discovered" (maybe popularized) the microbiome - or so she said - I asked for her autograph.
Name? What are you talking about?
Yes, met a young woman some years ago - sold her something on craigslist - she and her friend stopped by. We got to talking and her friend mentioned that she
"had discovered" the microbiome. This was in the original heyday of its initial popularity, around 2008. (I know it was discovered long ago, like a hundred years ago) I assumed she was a researcher and likely did her dissertation on it. So I jokingly asked for her autograph, which she declined. Back then the microbiome was famous, the key to life. Like DNA. I suppose they were just excited postdocs in a new field. You know how they are.
As always, the supplement industry didn't waste time flooding the online shops with offerings of Urolithin A, and as always, the problem numero uno for us, consumers, is to try to find which brand sell the real stuff.
Do you think it's bad that there's innovation targeted at new, potentially beneficial, compounds. That seems like a feature, not a bug
It is not intrinsically “bad”.
My point is about the lack of regulations regarding supplements; we have little guarantees, the product advertised is really what it is claimed.
Case in point: relative of mine used to work at BU School of Medicine as an analytical chemist. One of his colleagues is a very well known specialist of analysis of PUFAs, which a difficult endeavor.
EVERY contract he got to analyze the composition of PUFAs for manufacturers came with ironclad NDAs.
Why? Since > 90% of all the products he analyzed had substantially subpar quantity of active ingredients than the manufacturer claimed on the package insert, the request for signing NDAs prior to do the work was…unsurprising.
Too bad I keep kosher. And kosher roquefort (sp?) is very hard to find in Texas.
What a loss :(
10 - 12%?! Must be a misprint, otherwise gonna have to start eating acorns.
I dropped the data table, didn't I? Take a look. Grated, these were untrained sedentary people -- presumably lots of room to improve.
Crazy significance. Still, differential dose-responses on different muscle groups and also on strength vs. endurance? Them numbers are all over the chart.
That a confounder effect? Maybe time is a hidden confounder. Myostatin, IL-15, or recovery rate effects? Body-type, diet, or outcome-arm non randomization? The often ignored outer-space-alien Ai that's running this reality effect?
Might be good to see results after eight months.
I personally believe that any cohort not wearing Velostat hats is suspect.
https://www.stopabductions.com/
I bought some Velostat to line my hats; an experiment to discern a difference - and that shipment of Velostat impossibly disappeared from my desk! Not misplaced, either. I bought more but have not gotten to it yet in over a year; I seem to be blocked from completing my task.
Maybe by these really weird apparent bio-entities:
https://www.youtube.com/watch?v=xGtSUIDECMI
I wouldn't say confounder so much as 'modifier' ... variability like that is expected in a study like this.
Yes, modifier is good terminology, but there seems to be more directional modification going on than strength modification, which I'd think should be more common as dose response is more often more is more rather than the reversal, more is less.
With lots of subgroups a modifier could also be a confounder.
Your photo shows RED raspberries, not yellow.🫤
Could't find yellow at the store. You'll have to deal with it. I'm berry sorry.
Do you have a supplement recommendation?
I take AOR Urolithin A+. It also contains some Resveratrol, Spermidine, and NMN.
Putting a knife on the science paper for a little psycho touch? LOL
I enjoyed reading the newsletter, thanks for sharing the knowledge, the strategies and the possibilities.
Wanted to see if anyone commented. Farmer Bill's just sent me a bunch of biltong and the knife was just there... go figure.
Guess I pulled your trigger, enjoy the hit.
I do a lot of 'social media experiments' - ;)
This irritated me when first watching your channel. I feel it got more refined and I grew to like it, you're practically inquisitiveness personified. :^)
HA ... I love the candor