From the paper: ""Ketone bodies are janitors of damaged proteins, chaperoning away molecular waste so organisms can operate at peak molecular fitness."
WOW! What a fascinating and uplifting study. Hopefully, further research will ultimately lead to effective treatments and preventive measures in humans for this devastating disease. Thank you Nick for breaking down the science and explaining the mechanisms in these complicated papers in a manner all of us can understand. Please keep up the great work.
Ketosis seems to be the only effective way to manage most neurological conditions and we’ve known this for a long time but not the mechanism of action. Research like this that explains how it works which will be helpful to get skeptical scientists and lay people to endorse it. These findings are huge because what we are doing for Alzheimer’s disease now is not only unhelpful, it may be hurting people and there is nothing for prevention. This could bring hope. Thanks for bringing it to our attention and explaining it in an easy to understand way.
As someone with early onset dementia, THIS IS HUGE. I really am grappling with the N=1 approach to my own health but a ketone-inducing diet seems to be a smart approach on a number of fronts. Does that check out? Thanks from a newbie
Have you found the work of Dr Dale Bredesen? He has an excellent book called The End of Alzheimer’s and is very pro the keto diet, amoung many other things.
There isn't a strict threshold, but 0.5 mM is considered the lower bound of nutritional ketosis. And for matters pertaining to neurological and mental health, I like the 1 - 5mM range is probably a good target.
It’s so powerful how ketones works all around… and how much they remodel plasticity vs high glycemic variability which impairs protein folding and immunity and autophagy !!!
This is from Google's AI, but we're working on these things in the FB group Power Moms Autism Getting Healthy group:
"Both amyloid-beta and tau proteins are linked to autism spectrum disorder (ASD) and other brain disorders:
Amyloid-beta
An uncontrolled aggregation of amyloid-beta contributes to synaptic impairment and neuronal death.
Tau
A microtubule-associated protein (MAP) that is involved in the pathogenesis of ASD and other brain disorders. Tau is abundant in neurons and interacts with microtubules.
Here are some recent findings about the role of tau in autism:
Reducing tau levels can prevent autism symptoms
In mouse models of autism, reducing tau levels by 50% or more can prevent or significantly reduce autism-like behaviors, seizures, and brain enlargement.
Tau reduction may increase activity of PTEN
A reduction in tau levels may increase the activity of PTEN, a suppressor of the PI3K/Akt/mTOR signaling pathway. This pathway is commonly overactivated in ASD.
Tau-related therapies may be a viable treatment option
Tau-related therapies may be a viable treatment option for ASD, as there are already extensive research and development efforts for tau-reducing therapies for Alzheimer's disease. "
WOW! What a fascinating and uplifting study. Hopefully, further research will ultimately lead to effective treatments and preventive measures in humans for this devastating disease. Thank you Nick for breaking down the science and explaining the mechanisms in these complicated papers in a manner all of us can understand. Please keep up the great work.
Thank you Shaun. It's me absolute pleasure and privilege
Ketosis seems to be the only effective way to manage most neurological conditions and we’ve known this for a long time but not the mechanism of action. Research like this that explains how it works which will be helpful to get skeptical scientists and lay people to endorse it. These findings are huge because what we are doing for Alzheimer’s disease now is not only unhelpful, it may be hurting people and there is nothing for prevention. This could bring hope. Thanks for bringing it to our attention and explaining it in an easy to understand way.
You're welcome! Thanks for the comment and for engaging!
As someone with early onset dementia, THIS IS HUGE. I really am grappling with the N=1 approach to my own health but a ketone-inducing diet seems to be a smart approach on a number of fronts. Does that check out? Thanks from a newbie
Have you found the work of Dr Dale Bredesen? He has an excellent book called The End of Alzheimer’s and is very pro the keto diet, amoung many other things.
This is all happening in the last few months. Thank you for the suggested reading. I'll certainly find the book.
Thank you
Would like to know know what level of Ketosis is recommended
There isn't a strict threshold, but 0.5 mM is considered the lower bound of nutritional ketosis. And for matters pertaining to neurological and mental health, I like the 1 - 5mM range is probably a good target.
Thanks for this. You mentioned ALS. I guess ketones then may be helpful in that situation, too?
https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1329541/full
H U G E
Thanks Donald ;)
It’s so powerful how ketones works all around… and how much they remodel plasticity vs high glycemic variability which impairs protein folding and immunity and autophagy !!!
I think this would be helpful for autism also, which deals with amyloid and tau.
Autism deals with amyloid and tau? Tell me more...
This is from Google's AI, but we're working on these things in the FB group Power Moms Autism Getting Healthy group:
"Both amyloid-beta and tau proteins are linked to autism spectrum disorder (ASD) and other brain disorders:
Amyloid-beta
An uncontrolled aggregation of amyloid-beta contributes to synaptic impairment and neuronal death.
Tau
A microtubule-associated protein (MAP) that is involved in the pathogenesis of ASD and other brain disorders. Tau is abundant in neurons and interacts with microtubules.
Here are some recent findings about the role of tau in autism:
Reducing tau levels can prevent autism symptoms
In mouse models of autism, reducing tau levels by 50% or more can prevent or significantly reduce autism-like behaviors, seizures, and brain enlargement.
Tau reduction may increase activity of PTEN
A reduction in tau levels may increase the activity of PTEN, a suppressor of the PI3K/Akt/mTOR signaling pathway. This pathway is commonly overactivated in ASD.
Tau-related therapies may be a viable treatment option
Tau-related therapies may be a viable treatment option for ASD, as there are already extensive research and development efforts for tau-reducing therapies for Alzheimer's disease. "