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ilaria bertini's avatar

I am so fascinated about metabolic and brain health... and I see every day with many patients! the one improve te other and viceversa. it is interesting to, as a curious little woman, to speculate about the why... lactate is a signaling molecule and support energy for neurons and also the production of glutamate. to much kineurine and then maybe quinolinic acid maybe are signs of alert about something going wrong (inflammation, energy scarsity, inulin resistance, infection, misfolding proteins...)... do you think over expression of IDO1 in AD is maybe a way to inhibit lactate signals and so the glutamate hyper activity and the consequent excitotoxicity? oh oh oh what a great opportunity to be her my super hero @nick

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Penny's avatar

PF068 is a great name for that drug. Penny Figtree born 1968. 🩷

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