These aren’t easy questions to answer. But in this video, we will weigh into the debate and dissect these questions with the critical thought they deserve.
Yes, I remember reading about the Warburg effect which was first proposed almost 100 yrs ago, whereby cancer cells preferentially use glucose as their energy source. Also about Thomas Seyfried's metabolic theory of cancer. Perhaps we got so focused on cancer as a genetic disease that we stopped looking at other options. Often happens in science, but as you say, "stay curious". Theoretically, intermittent fasting and a strict glucose-free ketogenic diet could be helpful as a cancer treatment or even as an add-on treatment.
how about the trade off with polyphenols in fruit? if not nessessasry from fruit, can you get the full range from unrefined oils and nuts?
Also on a side note I would guess at some point the quantity of each fruit consumed (depending on their GI and amount of polyphenols) will reach a point where the fructose saturation will outweight such benefits the polyphenols give.
To your point, fruits aren't necessary to get various polyphenols, although they are options. Pomegranates and wild berries are among your best bets for fruits, as well as EVOO and raw nuts. I'll have more to say on this in upcoming videos. And if you want to get a sense of some of the literature I'll be delving into on this topic, see new in Cell Metabolism: "Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance"
I downloaded the study, looked at and studied it… I had similar thoughts about!!! The context is often missed… dosing fruit !? A lot of confusion about a portion size right for me or for you or for one with metabolic issues or gut issues.. acute vs chronic exposure… seasonal or not… and if I am in keto or lo carb and I want to eat seasonal berries or a peach from my father tree I MUST prepare me EXTREMELY GRADUALLY :))) than you Nick for your fabulous critical thinking 🫣😜💥
Yes, I remember reading about the Warburg effect which was first proposed almost 100 yrs ago, whereby cancer cells preferentially use glucose as their energy source. Also about Thomas Seyfried's metabolic theory of cancer. Perhaps we got so focused on cancer as a genetic disease that we stopped looking at other options. Often happens in science, but as you say, "stay curious". Theoretically, intermittent fasting and a strict glucose-free ketogenic diet could be helpful as a cancer treatment or even as an add-on treatment.
Certainly the Warburg effect is real, but this is a distinct mechanism.
how about the trade off with polyphenols in fruit? if not nessessasry from fruit, can you get the full range from unrefined oils and nuts?
Also on a side note I would guess at some point the quantity of each fruit consumed (depending on their GI and amount of polyphenols) will reach a point where the fructose saturation will outweight such benefits the polyphenols give.
To your point, fruits aren't necessary to get various polyphenols, although they are options. Pomegranates and wild berries are among your best bets for fruits, as well as EVOO and raw nuts. I'll have more to say on this in upcoming videos. And if you want to get a sense of some of the literature I'll be delving into on this topic, see new in Cell Metabolism: "Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance"
I downloaded the study, looked at and studied it… I had similar thoughts about!!! The context is often missed… dosing fruit !? A lot of confusion about a portion size right for me or for you or for one with metabolic issues or gut issues.. acute vs chronic exposure… seasonal or not… and if I am in keto or lo carb and I want to eat seasonal berries or a peach from my father tree I MUST prepare me EXTREMELY GRADUALLY :))) than you Nick for your fabulous critical thinking 🫣😜💥
Glad you found this useful :)