You may be able to trick your body into losing weight with a weighted vest. Remarkable research is showing how strategically mechanically loading your body can toggle your brain to decrease hunger.
Weight isn't regulated by one lever. Environmental + genetic factors can "conspire" to shift any individuals weight set "range" (not a point, a range). We talk about macronutrient shifts, insulin resistance, etc. That gravity might be a lever is fascinating, isn't it?
Not sure it’s about gradual vs immediate. Rather I think it’s that Gravity is just one lever - and probably not the most powerful in a real world setting.
My understanding is running is essentially jumping from one leg to the other this applies a large compressive force on that leg. Daniel Lieberman at Harvard has spoken about this being exactly the amount of force needed to promote new bone growth. I wonder if that is a reason why runners are notably skinny. Is running doing the same thing?
I had a similar thought, but I don’t think the gravitational/compression forces are spread over long enough duration for the gravity to play a very significant role in so far as your body won’t be “tricked” into thinking it’s heavier. However, it’s a good thought because the evolutionary logic is you want to be lean enough to be agile. It’s possible the brain could adjust the threshold on the gravitostat if it learns it needs to be moving around more as signaled by high mileage running. Make sense? Just a hypothesis.
You inspired me to get back to Rucking! Doing it as I was reading this article! Thanks Nick! Can you at some point do some deep dives into peptides like SLU- PP332 and 5Amino1MQ? Also what are your thoughts on carb cycling for those on a keto diet? Say eating carbs once a week? Any upside or what are the downsides?
Great content, Nick! I think about how expensive healthcare is and how we need to try and leverage effective and affordable intervention's, this could be low hanging fruit to help people! I also think (and maybe this is my cynic in me) that possibly effective and inexpensive interventions like this don't get the proper attention as compared to pharmaceutical interventions (to clarify, I am not against pharmacy). Do you have similar sentiment? How do we change the culture in medicine in that sense?
Fascinating! Last autumn I had the impression that I got leaner running hill intervals every Monday for about two months. I have since then had a theory that the body makes some adaptations. May this be it then?
loved this one, I am going to get a weighted vest....and of course we have always known that bone responds to loads or so I am reminded by my orthopod husband. I expect that they will discover more nuance in the follow up studies. At a minimum: Do you have to keep increasing the weight in the vest? or time of weating? would it work with a controlled low calorie diet as in teh study? etc etc
If I had to guess it has something to do with the epigenetic changes in osteocytes and the general slow turnover of bones. I wish they’d had intermediate follow-up points so we could see if there were a waning effect and - if so - when it kicked in.
Must be why rucking is so successful! The science behind it all. It's more than burning calories. The mystery is solved. I love it.
How dare you… the mystery is never full solved… that’s what makes science the gift that keeps on giving!
Very interesting indeed! Thank you. My handbag weighs a ton and I keep meaning to clear it out. I now won't bother!
“Rock on!” (Or rocks in … to the bag)
Why do overweight people remain overweight? They are loading their bones
Weight isn't regulated by one lever. Environmental + genetic factors can "conspire" to shift any individuals weight set "range" (not a point, a range). We talk about macronutrient shifts, insulin resistance, etc. That gravity might be a lever is fascinating, isn't it?
I see. Perhaps the gradual shift of gaining weight is accepted by the brain while a 10% load triggers the bone gage response
Not sure it’s about gradual vs immediate. Rather I think it’s that Gravity is just one lever - and probably not the most powerful in a real world setting.
Got it
My understanding is running is essentially jumping from one leg to the other this applies a large compressive force on that leg. Daniel Lieberman at Harvard has spoken about this being exactly the amount of force needed to promote new bone growth. I wonder if that is a reason why runners are notably skinny. Is running doing the same thing?
I had a similar thought, but I don’t think the gravitational/compression forces are spread over long enough duration for the gravity to play a very significant role in so far as your body won’t be “tricked” into thinking it’s heavier. However, it’s a good thought because the evolutionary logic is you want to be lean enough to be agile. It’s possible the brain could adjust the threshold on the gravitostat if it learns it needs to be moving around more as signaled by high mileage running. Make sense? Just a hypothesis.
You inspired me to get back to Rucking! Doing it as I was reading this article! Thanks Nick! Can you at some point do some deep dives into peptides like SLU- PP332 and 5Amino1MQ? Also what are your thoughts on carb cycling for those on a keto diet? Say eating carbs once a week? Any upside or what are the downsides?
Glad you liked the letter! Here are thoughts on carb cycling: The What, How, Why… and WOW of Carb Cycling
https://youtu.be/1DboMQ9PBIM
Thanks Nick!
Welcome!
Great content, Nick! I think about how expensive healthcare is and how we need to try and leverage effective and affordable intervention's, this could be low hanging fruit to help people! I also think (and maybe this is my cynic in me) that possibly effective and inexpensive interventions like this don't get the proper attention as compared to pharmaceutical interventions (to clarify, I am not against pharmacy). Do you have similar sentiment? How do we change the culture in medicine in that sense?
Fascinating! Last autumn I had the impression that I got leaner running hill intervals every Monday for about two months. I have since then had a theory that the body makes some adaptations. May this be it then?
Body absolutely makes adaptations. And hill runs are killer! Nice work.
loved this one, I am going to get a weighted vest....and of course we have always known that bone responds to loads or so I am reminded by my orthopod husband. I expect that they will discover more nuance in the follow up studies. At a minimum: Do you have to keep increasing the weight in the vest? or time of weating? would it work with a controlled low calorie diet as in teh study? etc etc
Glad you liked the letter. For sure, many more answers to unpack! That's the fun part!
Any idea if this will work with those of us over 80 with sarcopenia?
I see no reason why not.
maybe after the first 6 months, your body thinks you lost weight, so now your appetite is lower?
If I had to guess it has something to do with the epigenetic changes in osteocytes and the general slow turnover of bones. I wish they’d had intermediate follow-up points so we could see if there were a waning effect and - if so - when it kicked in.