We will discuss new literature in Science & Cell Metabolism about GLP-1 receptor agonists, inflammation, the brain and overall health. Get ready for nuance...
Being on Ozempic (briefly but used for 2 weeks) I noticed my internet shopping desire dried up. Completely. I've heard other addictions have ceased with GLP-1's. To me that is more profound than weight loss if it holds true.
Thank you Nick for this. GLP1 will be adjunct for some as long as the foundation is solid. Maybe a bit of "icing on the cake" . I see many who struggle achieve some confidence and success w low dose GLP1 and support/education. We are refining our protocol and patient handouts
As someone who has an autoimmune disorder (two actually, if you believe in the multiple autoimmune theory vs an umbrella theory), GLP-1 agonists are highly tempting. I have seen many who are “carnivoring harder”, and the benefits of a low inflammatory diet are slow going without the “miraculous” effects. It’s tempting to give in and add these medications. I know several who are choosing the path of least resistance. But my biggest concern is will the effects go away after withdrawal of medication? None of the studies I have read (which is by no means all written on the subject) address what happens after withdrawal of GLP-1 agonists. When used correctly for obesity, these meds can be weaned off, while lifestyle changes take the reins. But will someone with chronic inflammatory conditions ever be able to wean off? I suspect not, as it’s not ultimately correcting the root cause, even if you are eating the cleanest diet possible. It is tempting…but I personally do not know if I’m willing to pay a lifelong cost. I would love to see these studies continued beyond the positive effects without the drug to see how long the effects last. Just my thoughts.
can not agree more. weight is a result of a well functioning human being. I tell this to every one of my patients. GLP 1 agonist can be useful but, as you said, it must be give to selected people. may be not for weight loss
the back bone of health start with lifestyle. and yes, as society, we have to let people know more and be supported alla around
Being on Ozempic (briefly but used for 2 weeks) I noticed my internet shopping desire dried up. Completely. I've heard other addictions have ceased with GLP-1's. To me that is more profound than weight loss if it holds true.
There definitely seems to be a signal in the literature. I know the relationship to alcohol use is being actively studied.
Thank you Nick for this. GLP1 will be adjunct for some as long as the foundation is solid. Maybe a bit of "icing on the cake" . I see many who struggle achieve some confidence and success w low dose GLP1 and support/education. We are refining our protocol and patient handouts
Nice analogy ;). Thanks for the thoughts. I agree.
As someone who has an autoimmune disorder (two actually, if you believe in the multiple autoimmune theory vs an umbrella theory), GLP-1 agonists are highly tempting. I have seen many who are “carnivoring harder”, and the benefits of a low inflammatory diet are slow going without the “miraculous” effects. It’s tempting to give in and add these medications. I know several who are choosing the path of least resistance. But my biggest concern is will the effects go away after withdrawal of medication? None of the studies I have read (which is by no means all written on the subject) address what happens after withdrawal of GLP-1 agonists. When used correctly for obesity, these meds can be weaned off, while lifestyle changes take the reins. But will someone with chronic inflammatory conditions ever be able to wean off? I suspect not, as it’s not ultimately correcting the root cause, even if you are eating the cleanest diet possible. It is tempting…but I personally do not know if I’m willing to pay a lifelong cost. I would love to see these studies continued beyond the positive effects without the drug to see how long the effects last. Just my thoughts.
Fair thoughts. I'd speculate that the benefits - if any - would disappear once the medication is terminated.
can not agree more. weight is a result of a well functioning human being. I tell this to every one of my patients. GLP 1 agonist can be useful but, as you said, it must be give to selected people. may be not for weight loss
the back bone of health start with lifestyle. and yes, as society, we have to let people know more and be supported alla around
"Supported all around" ... couldn't agree more. Complex and 'touchy" issue... one that needs to be discussed with shades of gray.
🧠💥🫣