26 Comments

I am suffering now in hair loss since I reintroduced fasting in June 2024.

It happened despite the caloric surplus… I am digesting all the content reg this topic as situation is dramatic.

Will try with antioxidants

Expand full comment

Glad you found this interesting/useful.

Expand full comment

I am already bald and very sexy! I am not worried! But if my GF starts becoming bald, I will be!

Expand full comment

Haha. Own it brother!

Expand full comment

I guess I’ve read too much about HFCS - High Fructose Corn Syrup. Every time I read HFSC my brain filled in high fructose corn syrup. Acronym dyslexia.

Expand full comment

HFSC vs HFCS ... didn't even notice...

Expand full comment

I'm using topical DMSO for joint issues, but purported to have hair benefits as well, so another thing I might try. This is another forgotten treatment with multiple uses that is being rediscovered.

Expand full comment

What, the topical dimethyl sulfoxide?

Expand full comment

I'm not sure if the links to studies will open here, but it's a pretty thorough database of the research studies on DMSO. I'm usually extremely skeptical of products that claim to treat multiple disorders, but being a bit of a research freak I read many original studies and the process sounded interesting. My N=1 study trying it for late-stage hip arthritis and trying to avoid another hip replacement is turning out to be suprisingly successful, despite my initial skepticism. Like the Vit E for hair, I thought what is there to lose by trying?

https://substack.com/redirect/adb2891c-60cb-4bdb-9c66-021497316a42?j=eyJ1IjoibnEyaWsifQ.t974vXVd4XORNoJm7Q9EWRuGAblv5r14P13P5Wp-Y1A

Expand full comment

I would add that I personally found this very interesting because I have the same issue when I fast. I will be doing an N=1 with n-acetyl l-csrnosine, as it's the antioxidant I have on hand, and not fat soluble so possibly cosmetically improved. I won't be shaving my head, but I'll report on any perceived improvement.

Expand full comment

Oral or topical?

Expand full comment

Ok, fringe warning. I purchased it to mix into commercial eye drops, hearing that it could help with cataracts. I received a lot more product than I could possibly use, and read that it could be taken orally as an antioxidant / mood enhancer. I still have some left over. So now I'm going to try putting it on my head. I'm nothing if not curious.

Expand full comment

Well, you are curious!

Expand full comment

Since I know you've been trying to capture a larger audience, I should let you know I tried to present your article to my keto group, and they were very derisive. Basically they didn't read it at all, because of Dr. Evil and the somewhat sensationalist headline. Frustrating!

Expand full comment

Well if they don't like an Austin Power's joke that just speaks poorly to their sense of cultural and humor ;).

Expand full comment

Hi Nick. I’ve been Keto for a few years now with 6 months of strict carnivore (N=1) to see the difference. I’ve just added back some berries, heavy cream, avocado and am inching my way back to keto. Over the last 3-4 months my hair has begun to fall out 🤔. I had stopped fasting during the carnivore cycle and just did a 60 hr fast when your article popped up. I’ll also try the topical E and report back. I know we’re all different in response to treatment, but curious if there is a timeframe (or rough guesstimate) as to how long it takes to kick in. Also, was this daily or weekly application? Thanks for all the research you do and for the great content you post. Much appreciated! Gail

Expand full comment

Curious! I came on this study last week and smile! Maybe some patients are more fragile as the ones with alopecia, psoriasis or autoimmune disease but fascinating how different cells respond to the same stimuli maybe also in different times! Mitochondria overload in those area are suffering but vit E red and nir light and or cold can be helpful maybe locally!?

Expand full comment

I will definitely consider an N=1 experiment. I have had two severe sheddings with extended fasting, and even now doing IF with no caloric restriction I have an uneasy feeling about my follicle stability. Wondering if a water-soluble antioxidant is a possibility, as I doubt the cosmetic effects of rubbing E oil on my hair will be particularly attractive. Any suggestions?

Expand full comment

This might explain why my cat, who has severely reduced her food intake ( for unknown reasons to my vet) has lost all the fur off her back end, but appears to be surviving happily on very little food.

Fasting and TRF and keto diets do something else unfavourable- they dramatically increase your SHBG ( mine doubled after adding in weekly 48hr fasts for 3 months) which then reduced my free testosterone that I was trying to get from HRT. The testosterone is supposed to help me build muscle and lose weight and generally be a bit more enthused about life and I thought that having too much subcutaneous fat was aromatising it away to oestrogen, so I started the fasting which was way harder than when I was premenopausal. So, what to do? Should I eat more carbs to get my SHBG down, but then I’ll just get even fatter? It feels like a catch 22!

Expand full comment

Elevated SHBG isn't necessarily bad. It's not only just binding sex hormones but is also a signaling molecule in itself. That said, if your free sex hormones are low then it could be something worth tweaking. But bear in mind there is a lot of inter-individual variation. So, it's also not wise to chase high numbers for the sake of it. I suppose at the end of the say what matters most is how fasting makes you feel.

Expand full comment

Hmm I been doing IF for several years and definitely noticing thinning over the crown, which I assumed was genetic as my mother also had "female pattern balding" in this area. I just ordered some Vit E oil. Worth a try!

Expand full comment

Hard to know the contribution in any individual case. But - like you said/suggested - not much to lose... well... except...

Expand full comment

Over time I'm becoming convinced that fasting is not really optimal. We perceive it as good because it helps all the peolle who do something even worse: eat junk. But if you aren't eating junk fasting is likely detrimental. It may be very hard to eat enough if you have less time to eat.

Also, I've seen ton of carnivore people reporting problems when they didn't eat enough. Likely applies to keto as well. So I think claiming "it's not calories, they were equal" is misleading since maybe the fasting group needs to eat more in total? I'm speculating but I like to poke potential holes in scientific studies.

Expand full comment

I think fasting certainly has it's benefits, beyond CR. But growing a full head of hair isn't one of them.

Expand full comment

Thanks for helping us brush up on this side-effect of TRF/ADF. Would ingesting Vitamin E (or tocotrienol) pills be helpful, or would this still be a case of "hair today, gone tomorrow?"

Expand full comment

Nice pun. I think topical > oral if you are going to expirement.

Expand full comment
Error