Do you have any gut feeling about whether the metabolite anthranilic acid is low in food addicted patients due to a reduced ability to make the conversion from the amino acid or is it more likely to be due to a reduced intake of the amino acids more generally? Does that make sense?
My husband heard me listening to the article, and it makes him want to just start taking tyrosine and tryptophan and what I’m trying to understand is if there’s anything that makes you suspect that would, or wouldn’t be potentially beneficial. Like, what good is taking extra if you can’t make the conversion to the protective compound? I’m totally for it if it’s a simple matter of not getting enough of those amino acids but I don’t want to just throw money down the toilet on supplements if he can’t even make the conversion adequately, you know? Maybe some other gut rehab stuff is in order first.
I don't think it's an animo acid deficiency. It's not entirely clear if the supplementation would, presumably, shift Microviridae levels or if the Microviridae alters Tyr metabolism in such a way that the AA is depleted with other downstream effects on DA and 5HT metabolism. So, no, I can't really say. But I don't think there's anything commercially available right now to take. Also, it's a bit complicated but if you read the paper, the strongest relationships were overall seen in women, not men. There were same findings in men but there appears to be a sex-dependent element as well.
Thanks Nick. I haven’t had a chance to sit down & read (and attempt to digest) the paper but I put it on my To Do list. Probably while Thanksgiving baking happens later!
We have searched and searched for things to help him. He’s worked with Tro, he’s low carbed, he’s NOT short on willpower in 98% of the rest of his life. There’s something(s) we are missing and I am not stopping.
It was relatively easy for me to middle finger modern medical advice and hop on the keto train, cure decades of mental illness, drop 110+/- pounds, maintain it. For him it had been a frustrating lifelong roller coaster - since his pre-teen years. I finally figured out that “if I can do it you can do it” isn’t necessarily true or won’t work the same way, and rather than continuing to bash into “what should be” we have to learn to work with “what IS,” and fix THAT, to have a hope of getting to “what should be.” I’m here for it for as long as he doesn’t tell me point blank he gives up.
Don't let him give up. When he has someone like you in his corner, that shouldn't eve be an option. With the right support, a metabolic health journey should always be net progressive... even if it's two steps forward one step back progressive... best of luck and Happy Holidays
Well... I'd love to see a paper on "love" and microbiome... got a reference for that? I don't doubt it but hard to study. Wish we had more tailored protocols.
Thanks Ilaria. Doesn't seem like a study so much as a single author hypothesis paper about breakups and the microbiome. I'm not sure I'm all in on the idea that "romantic relationship dissolution is accompanied by decreased gut microbiota diversity which could be corrected with the ingestion of dietary fibers with an additional antidepressant benefit." Not sure chia seeds are the key to getting over a breakup... but that's just one man's opinion.
Time ago… and I am looking for some better studies. The gut brain or brain gut axis maybe implicated assuming that love can support the production and secretion of neuro peptides… active trough some bugs
In the lean mass hyperrespoders, what is the ratio of small particle LDL to large particle LDL? My guess is that large particle LDL is far more prevalent than small particle LDL.
Very clever to investigate a connection between viruses and obesity. This is exciting and unexpected. Truth (and Biology) is stranger than fiction.
Certainly the research will explode on this, because there is a fortune to be made.
Because addiction is addiction whether it be opioids, tobacco, alcohol or sugar, my guess is this virus could be involved in any form of addiction. It’s all about causing an imbalance or overproduction of neurotransmitters then logically it would be involved in any form of addiction.
Fascinating! Thanks for sharing this research.
very welcome Lara
Do you have any gut feeling about whether the metabolite anthranilic acid is low in food addicted patients due to a reduced ability to make the conversion from the amino acid or is it more likely to be due to a reduced intake of the amino acids more generally? Does that make sense?
My husband heard me listening to the article, and it makes him want to just start taking tyrosine and tryptophan and what I’m trying to understand is if there’s anything that makes you suspect that would, or wouldn’t be potentially beneficial. Like, what good is taking extra if you can’t make the conversion to the protective compound? I’m totally for it if it’s a simple matter of not getting enough of those amino acids but I don’t want to just throw money down the toilet on supplements if he can’t even make the conversion adequately, you know? Maybe some other gut rehab stuff is in order first.
I don't think it's an animo acid deficiency. It's not entirely clear if the supplementation would, presumably, shift Microviridae levels or if the Microviridae alters Tyr metabolism in such a way that the AA is depleted with other downstream effects on DA and 5HT metabolism. So, no, I can't really say. But I don't think there's anything commercially available right now to take. Also, it's a bit complicated but if you read the paper, the strongest relationships were overall seen in women, not men. There were same findings in men but there appears to be a sex-dependent element as well.
Thanks Nick. I haven’t had a chance to sit down & read (and attempt to digest) the paper but I put it on my To Do list. Probably while Thanksgiving baking happens later!
We have searched and searched for things to help him. He’s worked with Tro, he’s low carbed, he’s NOT short on willpower in 98% of the rest of his life. There’s something(s) we are missing and I am not stopping.
It was relatively easy for me to middle finger modern medical advice and hop on the keto train, cure decades of mental illness, drop 110+/- pounds, maintain it. For him it had been a frustrating lifelong roller coaster - since his pre-teen years. I finally figured out that “if I can do it you can do it” isn’t necessarily true or won’t work the same way, and rather than continuing to bash into “what should be” we have to learn to work with “what IS,” and fix THAT, to have a hope of getting to “what should be.” I’m here for it for as long as he doesn’t tell me point blank he gives up.
Don't let him give up. When he has someone like you in his corner, that shouldn't eve be an option. With the right support, a metabolic health journey should always be net progressive... even if it's two steps forward one step back progressive... best of luck and Happy Holidays
how many guys we are in one!!!!
so many of what happens is mediated by the biome, cool, curious, but also a bit strange
we can modulate the biome trough lifestyle, diet, breath, temperature, light, environment, nature and love and connection... thank you @nick
Well... I'd love to see a paper on "love" and microbiome... got a reference for that? I don't doubt it but hard to study. Wish we had more tailored protocols.
hey @nick I saved this one https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.655038/full
Hey @nick did you take a look 👀 at this study above about love!? Have a great holiday time!!! 3,2,1 🥷🏋🏽♂️⛰️
Thanks Ilaria. Doesn't seem like a study so much as a single author hypothesis paper about breakups and the microbiome. I'm not sure I'm all in on the idea that "romantic relationship dissolution is accompanied by decreased gut microbiota diversity which could be corrected with the ingestion of dietary fibers with an additional antidepressant benefit." Not sure chia seeds are the key to getting over a breakup... but that's just one man's opinion.
https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1372274/full
This was a paper found some
Time ago… and I am looking for some better studies. The gut brain or brain gut axis maybe implicated assuming that love can support the production and secretion of neuro peptides… active trough some bugs
I was responding to the ad regarding The Cholesterol Code
Got it. Exciting.
In the lean mass hyperrespoders, what is the ratio of small particle LDL to large particle LDL? My guess is that large particle LDL is far more prevalent than small particle LDL.
Your guess would be correct. Almost exclusively pattern A.
Very clever to investigate a connection between viruses and obesity. This is exciting and unexpected. Truth (and Biology) is stranger than fiction.
Certainly the research will explode on this, because there is a fortune to be made.
Because addiction is addiction whether it be opioids, tobacco, alcohol or sugar, my guess is this virus could be involved in any form of addiction. It’s all about causing an imbalance or overproduction of neurotransmitters then logically it would be involved in any form of addiction.
I agree it's more complex than one virus one addiction