New research in Nature has identified a bile acid called Lithocholic Acid (LCA) that could be the missing link between caloric restriction and improvements in lifespan and health span.
There are many species and subspecies, although Lactobacillus, Clostridium and Eubacterium species are mentioned in the paper. The more sensible thing to do, imo, is engage in practices thought to increase endognenous production, like fasting. But for a straight answer to your question, it's Lactobacillus, Clostridium and Eubacterium species.
The paper just lists the genus, different species (Lb. plantarum) can produce different levels and Lactobacillus is composed of over 170 species. There is even high variations at the strains level see Fig 2a and Fig4 in
(1) Wouldn't advise to hyper-dose as a supplement. I did not suggestion supplementation. (2) From recent Nature press paper (May 2024): "LCA was considered carcinogenic, but recent studies demonstrated that LCA has antitumor effects." (PMID: 38782891)
How might removing gall bladders affect all this🤔?? Been trying to promote keto and fasting to a niece (42) with metabolic syndrome. The answer always is: 'I can't do that because I don't have a gallbladder'. (She had it removed at 38😞).
what a beautiful connection... liver, gut microbiome, muscle, brain, heart, mitochondria
and it's all physiology... we must operate to support that!!!!
CR, fasting, low carbs/keto diet, exercise... all AMPK enhancers
let's use curiosity to test if you aim to be fine all day long
Beautiful connection is right. I'm consistently in awe of metabolism and biology.
And I love so much you and your curious mind (or microbiome 😜)
What gut bacteria makes this bile acid? Perhaps a yogurt with this bacteria makes sense, I would like to try.
There are many species and subspecies, although Lactobacillus, Clostridium and Eubacterium species are mentioned in the paper. The more sensible thing to do, imo, is engage in practices thought to increase endognenous production, like fasting. But for a straight answer to your question, it's Lactobacillus, Clostridium and Eubacterium species.
The paper just lists the genus, different species (Lb. plantarum) can produce different levels and Lactobacillus is composed of over 170 species. There is even high variations at the strains level see Fig 2a and Fig4 in
https://www.nature.com/articles/s41598-020-58069-5 where the LCA production varies significantly among strains of Lb. plantarum
What about its potential adverse effects? "cholestasis and tumorigenesis" are a little off-putting...https://www.medchemexpress.com/Lithocholic-acid.html?srsltid=AfmBOorvR--OVKqKRbSzQR5OIMZNdyCktQrC6bH42T-GYTJs38VXWwqX
(1) Wouldn't advise to hyper-dose as a supplement. I did not suggestion supplementation. (2) From recent Nature press paper (May 2024): "LCA was considered carcinogenic, but recent studies demonstrated that LCA has antitumor effects." (PMID: 38782891)
How might removing gall bladders affect all this🤔?? Been trying to promote keto and fasting to a niece (42) with metabolic syndrome. The answer always is: 'I can't do that because I don't have a gallbladder'. (She had it removed at 38😞).
It shouldn't have a major effect. You still make bile and bile acids without a gallbladder.