StayCurious Metabolism

StayCurious Metabolism

The Oldest Woman (117) Had “High” Cholesterol — Here’s What That Really Means

A deeper look at what one supercentenarian’s labs can teach us about aging, cholesterol, and what really matters for long-term health.

Nick Norwitz MD PhD's avatar
Nick Norwitz MD PhD
Sep 28, 2025
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As a metabolism scientist, I was thrilled to see this a new paper published just days ago: a deep dive into the metabolism of the oldest living woman who lived to 117!

But as I was reading, I noticed something odd: her LDL cholesterol—a biomarker most doctors obsess over—was ‘missing’ from the main text. Curious…

After digging into the supplement, I finally found it in a single line of Supplemental Figure 8B… and it was high. Admittedly, it wasn’t astronomically high, but it was indicated as above the “recommended range.”

But that was only one of the many interesting details buried in this treasure-trove of data! So let’s delve in deeper and find out what sets this supercentenarian apart…

An old person with a cake

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In this special deep dive into the biology of the world’s oldest verified woman (117), we cover:

  • Who She Was, and Her Story

  • The ‘Paradox’ in Her Telomeres, which shorten with age

  • Mighty Mito! How Her Mitochondria Looked Decades Younger

  • Her Lipid and Metabolic Health Markers (Beyond Cholesterol)

  • Her Meal Plan, covering exactly what she ate, including specific brands of yogurt containing the bacterial strains the supercentenarian consumed daily

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